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The Aquascape Praziquantel Treatment is Used For the Treatment of External and Internal Parasites, Flukes, Flatworms and Tapeworm. Praziquantel is known to be one of the safest most effective pond fish medications available for treating a vast array of external and internal parasites. It will not stress pond fish, damage filtration systems, or negatively affect the balance of your pond. One of the biggest advantages in large ponds is that water changes are not necessary and it only takes one treatment.